Current Research Publications


Naturally Occurring Osmolytes Modulate the Nano-Mechanical Properties of Polycystic Kidney Disease (PKD) Domains
L Ma, M Xu, and AF Oberhauser
J Bio Chem. Publiches online October 11, 2010. PubMed Link

Water Prescription in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study
CJ Wang, C Creed, FT Winklhofer, and JJ Grantham
Clin J Am Soc Nephrol 5. Published online September 28, 2010. PubMed Link

Evaluation and Management of Pain in Autosomal Dominant Polycystic Kidney Disease
MC Hogan and SM Norby
Advances in Chronic Kidney Disease, Vol 17, No 3 (May), 2010: pp e1-e16. PubMed Link

Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease
MC Hogan, TV Masyuk, LJ Page, VJ  Kubly, EJ Bergstralh, X Li, B Kim, BF King, J Glockner, DR Holmes III, S Rossetti, PC Harris, NF LaRusso, and VE Torres
J Am Soc Nephrol  2010 Jun;21(6):1052-61. Epub 2010 Apr 29. PubMed Link

Sirolimus Therapy to Halt the Progression of ADPKD
N Perico, L Antiga, A Caroli, P Ruggenenti, G Fasolini, M Cafaro, P Ondei, N Rubis, O Diadei, G Gherardi, S Prandini, A Panozo, RF Bravo, S Carminati, FR Leon, F Gaspari, M Cortinovis, N Motterlini, B Ene-Iordache, A Remuzzi and G Remuzzi
J Am Soc Nephrol. Published online May, 2010PubMed Link

Molecular diagnostics for ADPKD
PC Harris and S Rossetti
S. Nat. Rev. Nephrol. Published online February, 2010. PubMed Link

A Pilot Clinical Study to Evaluate Changes in Urine Osmolatity and Urine cAMP in Response to Acute and Chronic Water Loading in ADPKD
I Barash, MP Ponda, DS Goldfarb, and EY Skolnik
Clin J Am Soc Nephrol 2010. Published online February, 2010. PubMed Link

Imaging for the prognosis of ADPKD
KT Bae and JJ Grantham
Nat. Rev. Nephrol. 2010. 6: 96-106. PubMed Link

Glomerulocystic kidney disease.
JJ Bissler, BJ Siroky, and H Yin
Pediatr Nephrol 2010. Published online January, 2010. PubMed Link

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1
JM Shillingford, KB Piontek, GG Germino, and T Weimbs
J Am Soc Nephrol 2010. Published online January, 2010. PubMed Link

The HALT Polycystic Kidney Disease Trials: Design and Implementation
AB Chapman, VE Torres, RD Perrone, TI Steinman, KT Bae, JP Miller, DC Miskulin, FR Oskoui, A Masoumi, MC Hogan, FT Winklhofer, W Braun, PA Thompson, CM Myers, C Kelleher, and R W Schrier
Clin J Am Soc Nephrol 2010. 5. 102-109. PubMed Link


Chemical Modifier Screen Identifies HDAC Inhibitors as Suppressors of PKD Models
Y Cao, N Semanchik, SH Lee, S Somlo, PE Barbano, R Coifman and Z Sun
PNAS published 4 December 2009, 10.1073/pnas.0911987106. PubMed Link

Renal Primary Cilia Lengthen after Acute Tubular Necrosis
E Verghese, SD Ricardo, R Weidenfeld, J Zhuang, PA Hill, RG Langham and JA Deane
J AM Soc Nephrol 2009. 20: 2147-2153. PubMed Link

The Role of the Mammalian Target of Rapamycin (mTOR) in Renal Disease
W Lieberthal and JS Levine
J AM Soc Nephrol 2009. Published online November, 2009. PubMed Link

Identification of a unique urinary biomarker profile in patients with ADPKD
A Kistler, H Mischak, M Danka, RP Wuthrich and AL Serra
Kidney Int 2009. 76(1): 89-96. PubMed Link

Renal Volume, Renin-Angiotensin-Aldosterone System, Hypertension, and Left Ventricular Hypertrophy in Patients with ADPKD
RW Schrier
J AM Soc Nephrol 2009. 20: 1888-1893. PubMed Link

Characterization of PKD Protein-Positive Exosome-Like Vesicles
MC Hogan, L Manganelli, JR Woollard, AI Masyuk, TV Masyuk, R Tammachote, BQ Huang, AA Leontovich, TG Beito, BJ Madden, MC Charlesworth, VE Torres, NF Russo, PC Harris, and CJ Ward
J AM Soc Nephrol 2009. 20: 278-88. PubMed Link

The cAMP Effectors Epac and Protein Kinase A(PKA) are Involved in the Hepatic Cystogenesis of an Animal Model of ARPKD
JM Banales, TV Masyuk, SA Gradilone, AI Masyuk, JF Medina, and NF La Russo
Hepatology 2009. 49: 160-174. PubMed Link

Family History of Renal Disease Severity Predicts the Mutated Gene in ADPKD
M Barua, O Cil, AD Paterson, K Wang, N He, E Dicks, P Parfrey and Y Pei
J Am Soc Nephrol 2009. 20. 1833-1838. PubMed Link

Steriod-free maintenance immunosuppression in kidney transplantation: is it time to consider it as a standard therapy?
FL Luan, DE Steffick and AO Ojo
Kidney International 2009. 1-6. e-published July 2009. PubMed Link

Cutaneous Microcirculation Is Impaired in Early Autosomal Dominant Polycystic Kidney Disease
A Ramunni, P Bresica, D Quaranta, MS Bianco, P Ranieri, E Dolce and P Coratelli
Nephrol Clin Pract 2009. 113: c71-c75. PubMed Link

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)
I Zafar, FA Belibi, Z He and CL Edelstein
Nephrol Dial Transplant 2009. 24: 2349-2353. PubMed Link

Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function
PJ Azurmendi, AR Fraga, FM Galan, C Kotliar, EE Arrizurieta, MG Valdez, PJ Forcada, JS Santelha Stefan and RS Martin
Nephrol Dial Transplant 2009. 24: 2458-2463. PubMed Link

Polycystic Liver Disease
T Schnelldorfer, VE Torres, S Sakaria, CB Rosen and DM Nagorney
Ann Surg 2009. 250: 112-119. PubMed Link

PPARgamma agonists inhibit vasopressin-mediated anion transport in the MDCK-C7 cell line
C Nofziger, KK Brown, CD Smith, W Harrington, D Murray, J Bisi, TT Ashton, FP Maurio, K Kalsi, TA West, D Baines, and BL Blazer-Yost
Am J Physiol Renal Physiol 2009. 297: F55-F62. PubMed Link

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
A Takakura, L Contrino, X Zhou, JV Bonventre, Y Sun, BD Humphreys, and J Zhou
Human Molecular Genetics 2009. 18(14):2523-2531. PubMed Link

2008 Homer W. Smith Award: Insights into the Pathogenesis of Polycystic Kidney Disease from Gene Discovery
PC Harris
J Am Soc Nephrol 2009. 20: 1188-1198. PubMed Link

Safety and tolerability of sirolimus treatment in patients with ADPKD
AL Serra, AD Kistler, D Poster, F Krauer, O Senn, S Raina, I Pavik, K Rentsch, A Regeniter, D Weishaupt and RP Wuthrich
Nephrol Dial Transplant 2009. 1-9. e-published June, 2009. PubMed Link

A Case for Water in the Treatment of Polycystic Kidney Disease
V Torres, L Bankir and JJ Grantham
Clin J Am Soc Nephrol 2009. 4: 1140-1150, e-published 2009. PubMed Link

Quality of Life in Autosomal Dominant Polycystic Kidney disease Patients not yet on Dialysis
D Rizk, C Jurkovits, E Veledar, S Bagby, DA Baumgarten, F Rahbari-Oskoui, T Steinman and AB Chapman
Clin J Am Soc Nephrol 2009. 4: 560-566. PubMed Link

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
TR Hartman, D Liu, JT Zilfou, V Robb, T Morrison, T Watnick, and EP Henske
Hum Mol Genet. January 2009. 18(1): 151-163. e-published October, 2008. PubMed Link

TRPP2 channels regulate apoptosis through the Ca2plus concentration in the endoplasmic reticulum
T Wegierski, D Steffil, C Kopp, R Tauber, B Buchholz, R Nitschke, EW Kuehn, G Walz, and M Kottgen
The EMBO Journal. (2009). 1-10. PubMed Link

DNA Testing for Live Kidney Donors at Risk for Autosomal Dominant Polycystic Kidney Disease
E Huang, M Samaniego-Picota, T McCune, JK Melancon, RA Montgomery, R Ugarte, E Kraus, Karl Womer, H Rabb and T Watnick
Transplantation 2009. 87: 133-137. PubMed Link

MRI-based Kidney volume Measurements in ADPKD: Reliability and Effect of Gadolinium Enhancement
KT Bae, C Tao, F Zhu, JE Bost, AB Chapman, JJ Grantham, VE Torres, LM Guay-Woodford, CM Meyers, WM Bennett and Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)
Clin J AM Soc Nephrol 2009. 4: 719-725. PubMed Link 

Prospective Change in Renal Volume and Function in Children with ADPKD
MA Cadnapaphornchai, K McFann, JD Strain, A Masoumi, and RW Schrier
Clin J AM Soc Nephrol 2009. 4: 820-829. PubMed Link 

Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients
JL Nishiura, RFCA Neves, SRM Eloi, SMLF Cintra, SA Ajzen and IP Heilberg
Clin J AM Soc Nephrol 2009. 4: 838-844. PubMed Link 

Cardiovascular Abnormalities in Autosomal Dominant Polycystic Kidney Disease
T Ecder and RW Schrier
Nat. Rev. Nephrol. (2009) 5: 221-228. PubMed Link

Verification of Consumers’ Experiences and Perceptions of Genetic Discrimination and its impact on Utilization of Genetic Testing
K Barlow-Stewart, SD Taylor, SA Treloar, M Stranger and M Otlowski
Genet Med. 2009. 11(3):193-201. PubMed Link


Volume Progression in ADPKD: The Major Factor Determining Clinical Outcomes
JJ Grantham, AB Chapman and VE Torres
Clin J Am Soc Nephrol 2006. 1: 148-157. PubMed Link

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©2016, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.

©2016, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.