Patients affected by Autosomal Dominant Polycystic Kidney Disease (ADPKD) need a safe and effective long-term treatment regimen. Unfortunately, there are still no disease-specific treatment for ADPKD approved in the US. A rational step towards identifying such agents is to test therapies that have a proven safety profile with mechanisms of action that can counter the disease progression.
The purpose of this study is to investigate whether drinking increased amounts of water (water loading) might slow down polycystic kidney growth or kidney function decline. Water loading can cause the suppression of a pathway that causes fluid buildup and cyst growth. High water intake has been safely used in the clinical setting, such as in the case of kidney stone therapy. New York State tap water is widely available and safe, making it highly cost-effective as well.
Other: High Water Intake
- pre-existing diagnosis of Autosomal Dominant Polycystic Kidney Disease
- estimated glomerular filtration rate of 40 ml/min or greater
- urine osmolality > 400 mOsm/L
- estimated glomerular filtration rate less than 40 ml/min
- low blood sodium levels
- syndrome of inappropriate diuretic hormone
- use of thiazide diuretics or selective serotonin reuptake inhibitors (SSRIs)
- use of tolvaptan, another vasopressin receptor antagonist, vasopressin agonists or dDAVP
- contraindications to magnetic resonance imaging (MRI) (pacemakers, defibrillators, implanted electronic devices, metallic foreign body)
Ines G Chicos
Irina Barash, MD, MS