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Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults With ADPKD

This research study is being conducted to determine if the dietary supplement, curcumin, improves the function of blood vessels of children and young adults with autosomal dominant polycystic kidney disease (ADPKD.)

Participation information:

Inclusion criteria:

  • ADPKD diagnosis
  • Normal renal function (estimated glomerular filtration rate >80 mL/min/1.73m^2)
  • Ability to provide informed consent

Exclusion criteria:

  • Currently taking a curcumin supplement
  • Current smoking or history of smoking in the past 12 months
  • History of hospitalization within the last 3 months
  • Active infection or antibiotic therapy
  • Pregnancy, lactation, or unwillingness to use adequate birth control
  • Body-mass index >95th percentile in ages 6-17 or >40 kg/m2 in ages 18-25
  • Inability to cooperate with/clinical contraindication for MRI including severe claustrophobia, implants, devices, or non-removable body piercings

Participation will consist of nine sessions ranging from half an hour to either three hours (if under 18 years of age) or five hours (if 18 years of age or older). You will take the curcumin (or an inactive placebo) for one year and have safety labs drawn throughout the study as part of the nine sessions. Testing will take place at the Division of Renal Diseases and Hypertension Clinical Research Unit at the University of Colorado
Anschutz Medical Campus, and the MRI scan will take place at Children’s Hospital Colorado.

Contact Information

Diana George
303-724-1684
Diana.George@ucdenver.edu