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Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease (TAME)

This study will test to see if metformin is safe and if it is tolerated compared to placebo in adult Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with beginning stages of chronic kidney disease. We will also measure its effect on progression of kidney disease as reflected in the kidney size and the kidney function, along with its effect on kidney pain and quality of life.

Intervention:

Drug: Metformin

Participant information:

Inclusion criteria:

  • Subject has Autosomal Dominant Polycystic Kidney Disease
  • Subject is fluent in English

Exclusion criteria:

  • Subject is not on active military duty
  • Subject is not currently participating in another clinical trial
  • Subject’s current GFR is not <60 cc/min/1.73m2
  • Subject does not have diabetes
  • Subject does not have a systemic disease other than hypertension and PKD
  • Subject does not have a solitary kidney
  • Subject does not have an allergy or intolerance to metformin
  • Subject is not pregnant or lactating or intending to become pregnant within the next three years
  • Subject does not have an unstable or unclipped cerebral aneurysm
  • Subject does not have active coronary artery disease
  • Subject does not have an MRI incompatible device/implant
  • Subject does not have severe claustrophobia
  • Subject has not had any solid organ transplant
  • Subject does not have a Vitamin B12 deficiency
  • Subject does not currently take any medications that interact with metformin, such as nifedipine, furosemide, cationic drugs (amiloride, ranitidine, triamterene digoxin, procainamide, quinidine, vancomycin, trimethoprim)

Contact information:

Linda Whiting, MBA
412.641.2568
whitingls2@upmc.edu

Sharon Stover, RN, CCRP
412.246.6959
stoversl@upmc.edu

University of Maryland Medical Center
Charalett Diggs, RN
410.328.0207
cdiggs@medicine.umaryland.edu

University of Maryland Medical Center
Beth Scism, RN
410.328.0207
bscism@medicine.umaryland.edu

Tufts Medical Center
Peggy Healy
617.636.8117
mhealy2@tuftsmedicalcenter.org

Tufts Medical Center
Carly Tucker
617.636.7914
ctucker@tuftsmedicalcenter.org