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A Randomised Feasibility Trial of High Water Intake in Polycystic Kidney Disease

DRINK is an open-label randomised controlled feasibility trial of high versus ad libitum water intake in ADPKD.


Dietary Supplement: High water intake
Other: Ad libitum water intake

Participation criteria:

Inclusion criteria:

  • Have given written informed consent to participate
  • Aged 16 years or older
  • Have a diagnosis of ADPKD (fulfilling radiological diagnostic criteria ± genetic evidence)
    eGFR ≥ 20ml/min/1.73m2
  • Able to self-monitor urine SG

Exclusion criteria:

  • Inability to provide informed consent
  • eGFR < 20ml/min/1.73m2
  • Fluid overload states e.g. heart failure, cirrhosis, or requirement for fluid restriction
  • Confounding illness impacting on renal disease e.g. concomitant diabetes or glomerulonephritis
  • Treatment with diuretics for fluid overload (those on diuretics for hypertension may participate in the trial after a run-in period of 2 weeks)
  • Treatment with Tolvaptan in the last 4 weeks
  • Pregnancy or breastfeeding

Contact information:

Thomas F Hiemstra

Ragada El-Damanawi