PKD Research Conference Abstracts Early Imaging Biomarkers of ADPKD – Quantitative MRI and Texture Analysis in Murine Model Abnormal DNA methylation signatures identified by WGBS integrate PKD associated and unstudied signaling pathways. PC2 degradation is altered in Pkd1-null cells Kidney-targeting multimodal micelles towards polycystic kidney disease therapy Polycystin 1 is an atypical adhesion GPCR that responds to non-canonical WNT signals and inhibits GSK3β Phosphorylation insensitive 4E-BP1 reduces hyperproliferative phenotype in vitro CD8+ T-cells play an important role in halting cystogenesis and provide a novel target for slowing ADPKD progression. Dietary sodium content, renin-angiotensin system and cysts formation in ARPKD The TRPP2-dependent channel of renal primary cilia also requires TRPM3 Pkhd1-Pkd1 interact in a dose-dependent manner to exacerbate a dysregulated ciliary compartment Localization and Partners of polycystin 1 at MAMs and Mitochondria Characterization of P2rX7 knockout in PCK (Polycystic Kidney) rats Cystic Epithelial Vasopressin Type-2 Receptor Signaling Regulates Interstitial Fibrosis in Polycystic Kidney Disease Analyzing the effect of Notch inhibition on the progression of Polycystic Kidney Disease O-GlcNAcase Inhibition Slows PKD Development A Novel Porcine Model of ARPKD for Preclinical Studies Produced by Gene Editing. RGLS4326 inhibits miR-17 and reduces ADPKD progression in preclinical models Deletion of Ift-A gene, Thm1, has differential effects in cystic kidney disease mouse models Human-specific abnormal alternative splicing of the wild-type PKD1 gene induces premature termination of polycystin–1. The role of LKB1-AMPK signaling on renal mTOR and cyst progression in PKD Lack of α-intercalated cells to secrete NGAL as the cellular and molecular basis of urinary tract infection in autosomal dominant polycystic kidney disease. mTOR inhibition attenuates cyst formation in tmem67-based cystogenesis in zebrafish Investigating CD4 T cells in mouse models of cystic disease and human PKD patients High-throughput screening in human kidney organoids reveals a role for myosin in ADPKD cystogenesis ADPKD occurrence corresponds with PKD1 orthologs harboring guanine quadruplex sequence motifs Polycystin levels regulate cell death-survival response during nutrient starvation Clinical trial of Venglustat, a glucosylceramide synthase (GCS) inhibitor, is supported by preclinical and Phase 1 study data Magnetic Resonance Imaging of the Heart, Liver, and Kidneys of a Porcine Model of ARPKD CD206 Positive Renal Resident Macrophages Facilitate Cyst Progression in a Juvenile-induced Cilia Mutant Mouse Model A Preventative Strategy for Autosomal Dominant Polycystic Kidney Disease: An Economic Evaluation Beta-3 adrenergic receptors as novel potential mediators of the cystogenetic process in ADPKD Increased Stat3 activation in pre-cystic kidneys of Thm1 conditional knock-out mice Serum FGF23 and Klotho are associated with long-term renal outcomes in autosomal dominant polycystic kidney disease (PKD) Establishing Meaningful Patient-Centered Research Outcomes for Patients with PKD NADPH oxidase (NOX4) and mitochondrial abnormalities contribute to oxidative stress and endothelial dysfunction in young normotensive patients with autosomal dominant polycystic kidney disease (ADPKD). Posttranslational modifications of M2 pyruvate kinase as the controller of Warburg metabolism in PKD Zebrafish, C. elegans, and Polycystic Kidney Disease: Identifying potential disease biomarkers through comparative analysis.