Abnormal DNA methylation signatures identified by WGBS integrate PKD associated and unstudied signaling pathways.
Polycystin 1 is an atypical adhesion GPCR that responds to non-canonical WNT signals and inhibits GSK3β
CD8+ T-cells play an important role in halting
cystogenesis and provide a novel target for slowing
Cystic Epithelial Vasopressin Type-2 Receptor Signaling Regulates Interstitial Fibrosis in Polycystic Kidney Disease
Human-specific abnormal alternative splicing of the wild-type PKD1 gene induces premature termination of polycystin–1.
Lack of α-intercalated cells to secrete NGAL as the cellular and molecular basis of urinary tract infection in autosomal dominant polycystic kidney disease.
Clinical trial of Venglustat, a glucosylceramide synthase (GCS) inhibitor, is supported by preclinical and Phase 1 study data
CD206 Positive Renal Resident Macrophages Facilitate Cyst Progression in a Juvenile-induced Cilia Mutant Mouse Model
Serum FGF23 and Klotho are associated with long-term renal outcomes in autosomal dominant polycystic kidney disease (PKD)