PKD Research Conference Abstracts

Early Imaging Biomarkers of ADPKD – Quantitative MRI and Texture Analysis in Murine Model

Abnormal DNA methylation signatures identified by WGBS integrate PKD associated and unstudied signaling pathways.

PC2 degradation is altered in Pkd1-null cells

Kidney-targeting multimodal micelles towards polycystic kidney disease therapy

Polycystin 1 is an atypical adhesion GPCR that responds to non-canonical WNT signals and inhibits GSK3β

Phosphorylation insensitive 4E-BP1 reduces hyperproliferative phenotype in vitro

CD8+ T-cells play an important role in halting
cystogenesis and provide a novel target for slowing
ADPKD progression.

Dietary sodium content, renin-angiotensin system and cysts formation in ARPKD

Cystic Epithelial Vasopressin Type-2 Receptor Signaling Regulates Interstitial Fibrosis in Polycystic Kidney Disease

Analyzing the effect of Notch inhibition on the progression of Polycystic Kidney Disease

O-GlcNAcase Inhibition Slows PKD Development

A Novel Porcine Model of ARPKD for Preclinical Studies Produced by Gene Editing.

RGLS4326 inhibits miR-17 and reduces ADPKD progression in preclinical models

Deletion of Ift-A gene, Thm1, has differential effects in cystic kidney disease mouse models

Human-specific abnormal alternative splicing of the wild-type PKD1 gene induces premature termination of polycystin–1.

The role of LKB1-AMPK signaling on renal mTOR and cyst progression in PKD

Lack of α-intercalated cells to secrete NGAL as the cellular and molecular basis of urinary tract infection in autosomal dominant polycystic kidney disease.

mTOR inhibition attenuates cyst formation in tmem67-based cystogenesis in zebrafish

Investigating CD4 T cells in mouse models of cystic disease and human PKD patients

High-throughput screening in human kidney organoids reveals a role for myosin in ADPKD cystogenesis