Q: Why should people donate PKD kidneys for research?
A: Our core facility generates biological materials to be provided to PKD investigators across the country. Human ADPKD cells that are cultured from the cysts of the PKD kidneys are ideal for in vitro model systems since we can precisely control the growth conditions. These in vitro assays are important for testing specific hypotheses, drug screening and validating potential therapeutics.
Q: Is tissue donation anonymous?
A: Yes, the patient identifiers are removed at the hospital prior to shipping the tissues to our lab. The only information provided is age, sex, prior dialysis and/or transplant, blood urea nitrogen, creatinine levels and the gene mutation, if known. The use of human materials complies with federal regulations and was approved by the Institutional Review Board at the University of Kansas Medical Center.
Q: What biomaterials are distributed to PKD scientists?
A: Our core generates and provides a variety of biological materials (biomaterials) to investigators in a collaborative arrangement. These biomaterials include paraffin blocks of paraformaldehyde-fixed tissues, frozen tissues, tissue lysates (proteins), RNA, DNA, primary cells and cyst fluid.
Q: How do I donate PKD kidneys for research?
A: PKD kidneys are retrieved by participating hospitals at the request and consent of the patient. The PKD Foundation facilitates the retrieval of the kidneys and serves as a liaison between the patient and the core facility. There are no costs to the patient for tissue donation. Patients can obtain additional information on tissue donation by visiting kumc.edu/pkdbiomaterials or by calling the Foundation at 800.753.2873.
Q: I have a question that isn’t answered here. How can I learn more?
A: Please feel free to contact the PKD Foundation by email or at 800.753.2873 for more information!