Research news

A special issue on Cell Signaling in PKD, led by Drs. Albert C.M. Ong and Vicente E. Torres, and consisting of 30 papers from many respected members of the PKD research community.

July 2020

Cellular signaling in PKD foreword: dedicated to the memory of Dr. Jared James Grantham (1936–2016); without his vision, achievements and impact on countless collaborators and disciples, the field of Polycystic Kidney Disease would not be where it is today.

Laparoscopic bilateral nephrectomy at the time of kidney transplantation appears safe and feasible for ADPKD patients with living donors

September 2020

Development and validation of a fully automated approach for performing semantic segmentation of kidney cysts in MR images ADPKD patients

September 2020

New conclusions about PKHD1 and polycystic liver disease

September 2020

A new therapeutic concept using the FDA-approved drugs niclosamide and benzbromarone, and a TMEM16A-specific inhibitor in ADPKD mice

August 2020

Metabolic changes in PKD and their modulation as a potential target of systemic treatment

August 2020

SONG-PKD report on core outcomes sets for ADPKD trials

August 2020

A Patient Perspective on Genetic Testing for ADPKD

August 2020

Robotic ultrasound provides a rapid and accurate approach for noninvasively evaluating PKD in rodent models

August 2020

Measuring liver disease severity in ARPKD using magnetic resonance elastography

August 2020

The value of imaging, genotypic, and combined data to identify rapidly progressive ADPKD patients

August 2020

Qinzhe Wang, MS, PhD (University of Utah) awarded the Jared J. Grantham Research Fellowship

July 2020

Upregulated SEMA3C may contribute to survival of polycystic kidney epithelial cells

July 2020

Genetic reduction of cilium-length by targeting intraflagellar transport 88 protein impedes kidney and liver cysts formation

June 2020

Niacinamide well-tolerated in ADPKD patients, but no efficacy observed

June 2020

Genetic reduction of cilium length may offer novel therapeutic approaches for ADPKD

June 2020

Overview of in vivo and in vitro models for ADPKD

June 2020

More from HALT-PKD: KIM-1 and ADPKD progression

June 2020

MRI-based kidney T1 and T2 mapping as a non-invasive assessment of ARPKD progression

April 2020

An expanded imaging classification model for ADPKD

June 2020

A report on heathcare cost burden in ADPKD

April 2020

Identification of critically important consensus-based core outcome domains to be reported in trials

April 2020

Role of chemokines, innate and adaptive immunity in PKD

April 2020

A review of contributing factors of cardiovascular dysfunction in ADPKD

April 2020

The molecular impact of variants found in the TOP domain of polycystin-2

May 2020

Impaired mitochondrial structure and function play a role in PKD progression

April 2020

A review of outcomes reported in randomized trials conducted in patients with PKD

March 2020

Urinary exosomal miRNAs could serve as novel biomarkers of disease progression

March 2020

DNAJB11 mutations as described by atypical clinical presentations of ADPKD

March 2020

Development of a high-throughput screening platform of cancer drugs in a quest to repurpose them for ADPKD

March 2020

Understanding the interplay between dysregulation of cellular metabolism and cystogenesis is likely to uncover pathways that can be directly modulated to treat PKD

September 2019

A review of ciliary dysfunction in cystic disease and the questions that remain

December 2019

A review and discussion of the therapeutic potential of metabolic reprogramming strategies in ADPKD

February 2020

Tubular secretion could be impaired in ADPKD independent of GFR

January 2020

Dietary phosphate restriction slows renal cyst growth and fibrosis in Pcy/pcy mouse model of PKD

January 2020

Patient engagement in research design improves feasibility, acceptability, rigor and relevance

March 2019

New mutation associated with ADPKD found on ALG9 gene

November 2019

Utilizing mosaicism to provide informed prognostic information and fully characterize ADPKD populations

February 2020

Cystic cells in PKD may be metabolically inflexible and could be exploited by dietary interventions or supplementation

December 2019

Meta-analysis demonstrates that GFR slope might be a viable surrogate endpoint in clinical trials for CKD

September 2019

 

FDA Removes Partial Clinical Hold for Multiple Ascending Dose Study of RGLS4326

December 2019

Addressing the Need for Clinical Trial End Points in Autosomal Dominant Polycystic Kidney Disease: A Report From the Polycystic Kidney Disease Outcomes Consortium (PKDOC)

April 2019

FDA-approved cystic fibrosis drug, VX-809, may have potential utility for treating patients with ADPKD

December 2019

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan

October 2018

Ultrasound elastography is a useful noninvasive biomarker to detect and quantify liver fibrosis and portal hypertension in children with ARPKD

June 2019

PKD progression may be accelerated by commonly occurring renal crystal deposition that could be therapeutically controlled by relatively simple measures

July 2019

Metabolomics in ADPKD: how plasma metabolites and lipids are associated with kidney function and kidney volume in hypertensive patients

February 2019

A recent analysis on how race/ ethnicity affects progression and initiation of dialysis in ADPKD patients in the US

February 2019

How do cysts grow in ADPKD and how is it related to the gene?

June 2019

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