Research news
A special issue on Cell Signaling in PKD, led by Drs. Albert C.M. Ong and Vicente E. Torres, and consisting of 30 papers from many respected members of the PKD research community.
July 2020
Cellular signaling in PKD foreword: dedicated to the memory of Dr. Jared James Grantham (1936–2016); without his vision, achievements and impact on countless collaborators and disciples, the field of Polycystic Kidney Disease would not be where it is today.
Laparoscopic bilateral nephrectomy at the time of kidney transplantation appears safe and feasible for ADPKD patients with living donors
September 2020
Development and validation of a fully automated approach for performing semantic segmentation of kidney cysts in MR images ADPKD patients
September 2020
New conclusions about PKHD1 and polycystic liver disease
September 2020
A new therapeutic concept using the FDA-approved drugs niclosamide and benzbromarone, and a TMEM16A-specific inhibitor in ADPKD mice
August 2020
Metabolic changes in PKD and their modulation as a potential target of systemic treatment
August 2020
SONG-PKD report on core outcomes sets for ADPKD trials
August 2020
A Patient Perspective on Genetic Testing for ADPKD
August 2020
Robotic ultrasound provides a rapid and accurate approach for noninvasively evaluating PKD in rodent models
August 2020
Measuring liver disease severity in ARPKD using magnetic resonance elastography
August 2020
The value of imaging, genotypic, and combined data to identify rapidly progressive ADPKD patients
August 2020
Qinzhe Wang, MS, PhD (University of Utah) awarded the Jared J. Grantham Research Fellowship
July 2020
Upregulated SEMA3C may contribute to survival of polycystic kidney epithelial cells
July 2020
Genetic reduction of cilium-length by targeting intraflagellar transport 88 protein impedes kidney and liver cysts formation
June 2020
Niacinamide well-tolerated in ADPKD patients, but no efficacy observed
June 2020
Genetic reduction of cilium length may offer novel therapeutic approaches for ADPKD
June 2020
Overview of in vivo and in vitro models for ADPKD
June 2020
More from HALT-PKD: KIM-1 and ADPKD progression
June 2020
MRI-based kidney T1 and T2 mapping as a non-invasive assessment of ARPKD progression
April 2020
An expanded imaging classification model for ADPKD
June 2020
A report on heathcare cost burden in ADPKD
April 2020
Identification of critically important consensus-based core outcome domains to be reported in trials
April 2020
Role of chemokines, innate and adaptive immunity in PKD
April 2020
A review of contributing factors of cardiovascular dysfunction in ADPKD
April 2020
The molecular impact of variants found in the TOP domain of polycystin-2
May 2020
Impaired mitochondrial structure and function play a role in PKD progression
April 2020
A review of outcomes reported in randomized trials conducted in patients with PKD
March 2020
Urinary exosomal miRNAs could serve as novel biomarkers of disease progression
March 2020
DNAJB11 mutations as described by atypical clinical presentations of ADPKD
March 2020
Development of a high-throughput screening platform of cancer drugs in a quest to repurpose them for ADPKD
March 2020
Understanding the interplay between dysregulation of cellular metabolism and cystogenesis is likely to uncover pathways that can be directly modulated to treat PKD
September 2019
A review of ciliary dysfunction in cystic disease and the questions that remain
December 2019
A review and discussion of the therapeutic potential of metabolic reprogramming strategies in ADPKD
February 2020
Tubular secretion could be impaired in ADPKD independent of GFR
January 2020
Dietary phosphate restriction slows renal cyst growth and fibrosis in Pcy/pcy mouse model of PKD
January 2020
Patient engagement in research design improves feasibility, acceptability, rigor and relevance
March 2019
New mutation associated with ADPKD found on ALG9 gene
November 2019
Utilizing mosaicism to provide informed prognostic information and fully characterize ADPKD populations
February 2020
Cystic cells in PKD may be metabolically inflexible and could be exploited by dietary interventions or supplementation
December 2019
Meta-analysis demonstrates that GFR slope might be a viable surrogate endpoint in clinical trials for CKD
September 2019 
FDA Removes Partial Clinical Hold for Multiple Ascending Dose Study of RGLS4326
December 2019
Addressing the Need for Clinical Trial End Points in Autosomal Dominant Polycystic Kidney Disease: A Report From the Polycystic Kidney Disease Outcomes Consortium (PKDOC)
April 2019
FDA-approved cystic fibrosis drug, VX-809, may have potential utility for treating patients with ADPKD
December 2019
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan
October 2018
Ultrasound elastography is a useful noninvasive biomarker to detect and quantify liver fibrosis and portal hypertension in children with ARPKD
June 2019
PKD progression may be accelerated by commonly occurring renal crystal deposition that could be therapeutically controlled by relatively simple measures
July 2019
Metabolomics in ADPKD: how plasma metabolites and lipids are associated with kidney function and kidney volume in hypertensive patients
February 2019
A recent analysis on how race/ ethnicity affects progression and initiation of dialysis in ADPKD patients in the US
February 2019
How do cysts grow in ADPKD and how is it related to the gene?
June 2019
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