Federal support plays a critical role in advancing research that improves treatments and moves us closer to cures for polycystic kidney disease (PKD). Below, learn more about two of the most important federal programs supporting PKD research: the National Institutes of Health and the Department of Defense's Congressionally Directed Medical Research Program.
National Institutes of Health (NIH)

The National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services (HHS), is the nation’s largest public funder of biomedical research and the primary federal source of funding for polycystic kidney disease (PKD) research. Within NIH, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) supports the majority of federally funded PKD research through investigator-initiated grants, research centers, and clinical studies.

Department of Defense

Congressionally Directed Medical Research Program (CDMRP)

Home to the Peer Reviewed Medical Research Program (PRMRP), an important source of federal funding for PKD research.

Established by Congress in 1992, the Congressionally Directed Medical Research Program (CDMRP) manages competitive biomedical research programs within the Department of Defense (DoD).

Administered by the DoD, the CDMRP supports research that benefits service members, veterans, military families, and the broader public. Through the Peer Reviewed Medical Research Program, the CDMRP has become an important source of federal investment in PKD research.

PKD Cures Act (H.R. 9169)

The bipartisan PKD Cures Act (H.R. 9169) is the first federal legislation focused exclusively on advancing research for polycystic kidney disease (PKD).

The legislation would strengthen NIH’s commitment to PKD research by expanding research efforts, improving collaboration across the scientific community, supporting more effective clinical trials, and establishing a coordinated long-term federal research strategy.

It also requires the NIH to develop a long-term research roadmap to guide federal investment, accelerate scientific discovery and the development of new treatments while moving the field closer to a cure.

Peer Reviewed Medical Research Program (PRMRP)

The Peer Reviewed Medical Research Program (PRMRP) is one of CDMRP's competitive research funding programs, supporting innovative research across numerous diseases and conditions that affect both military and civilian populations. A hallmark of the program is its two-tier review process, in which scientific experts evaluate proposals for scientific merit while patient advocates help assess their potential impact on the communities they serve.

PKD researchers have secured more than $47 million in PRMRP funding, supporting two major clinical trials—metformin and statins—as well as numerous basic science projects.