FALCON is a Phase 3 clinical study evaluating the effectiveness and safety of bardoxolone methyl (an oral investigational drug) in patients with Autosomal Dominant PKD.

Before participating in FALCON, patients must complete two screening visits at one of the study centers. Eligible patients will be randomly assigned (like the flip of a coin) to receive either bardoxolone methyl or placebo (an inactive capsule). The group of patients assigned to bardoxolone methyl will be compared to the group of patients assigned to placebo in order to help researchers better understand the effects on PKD.

The investigational drug, study-related procedures and doctor visits will be provided at no cost. If you travel to the site for your study visits, travel expenses will be reimbursed and compensation for study-related time may be compensated.


You may be eligible for this study if you:
● Are between 18 to 70 years of age
● Have been diagnosed with ADPKD
● Have a lab value eGFR between 30 to 90 mL/min/1.73 m2 (18 to 55 years old) or between 30 to 44 mL/min/1.73 m2 (56 to 70 years old)

Exclusion Criteria:
● Uncontrolled diabetes;
● History of intracranial aneurysms;
● Kidney or any other solid organ transplant recipient or a planned transplant during the study;
● Systemic immunosuppression for more than 2 weeks or anticipated need for immunosuppression during the study;
● Women who are pregnant or breastfeeding;


If you’re interested in participating, contact the Study Manager at:
+1 469-442-4754




University of Alabama at Birmingham

Birmingham, Alabama, United States, 35294

Principal Investigator: Dana Rizk, MD


Nephrology Consultants, LLC

Huntsville, Alabama, United States, 35805

Principal Investigator: Michael Quadrini, MD




Glendale, Arizona, United States, 85306

Principal Investigator: Peter Santos, MD


Aventiv Research, Inc

Mesa, Arizona, United States, 85210

Principal Investigator: Mandeep Sahani, MD


University of Arizona

Tucson, Arizona, United States, 85719

Principal Investigator: Frank Brosius, MD



California Institute Renal Research

La Mesa, California, United States, 91942

Principal Investigator: George Fadda, MD


University of California, Los Angeles

Los Angeles, California, United States, 90025

Principal Investigator: Anjay Rastogi, MD


Apex Research of Riverside

Riverside, California, United States, 92505

Principal Investigator: Joseph Lee, MD



Western Nephrology

Arvada, Colorado, United States, 80002

Principal Investigator: Harmeet Singh, MD



Yale University School of Medicine

New Haven, Connecticut, United States, 06520

Principal Investigator: Neera Dahl, MD



Volunteer Medical Research

Port Charlotte, Florida, United States, 33952

Principal Investigator: Kianoosh Kaveh, MD


Florida Premier Research Institute, LLC

Winter Park, Florida, United States, 32789

Principal Investigator: Jorge Kusnir, MD



Emory University

Atlanta, Georgia, United States, 30322

Principal Investigator: Frederic Rahbari-Oskoui, MD



Boise Kidney & Hypertension, PLLC

Caldwell, Idaho, United States, 83605

Principal Investigator: Arnold Silva, MD


Boise Kidney & Hypertension, PLLC

Meridian, Idaho, United States, 83642

Principal Investigator: Arnold Silva, MD



Northwestern University

Chicago, Illinois, United States, 60611

Principal Investigator: Jennifer Tuazon, MD


University of Chicago

Chicago, Illinois, United States, 60617

Principal Investigator: Arlene Chapman, MD


NorthShore University HealthSystem

Evanston, Illinois, United States, 60201

Principal Investigator: Stuart Sprague, MD



University of Kansas Medical Center

Kansas City, Kansas, United States, 66224

Principal Investigator: Kerri McGreal, MD


Kansas Nephrology Research Institute, LLC

Wichita, Kansas, United States, 67214

Principal Investigator: Dennis Ross, MD



Renal Associates of Baton Rouge

Baton Rouge, Louisiana, United States, 70808

Principal Investigator: Michael Roppolo, MD


Northwest Louisiana Nephrology

Shreveport, Louisiana, United States, 71101

Principal Investigator: Marwan Kaskas, MD



University of Maryland School of Medicine

Baltimore, Maryland, United States, 21201

Principal Investigator: Stephen Seliger, MD



Tufts Medical Center

Boston, Massachusetts, United States, 02111

Principal Investigator: Ronald Perrone, MD


Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States, 02215

Principal Investigator: Theodore Steinman, MD



Paragon Health PC d/b/a Nephrology Center PC

Kalamazoo, Michigan, United States, 49007

Principal Investigator: Than Oo, MD


Michigan Kidney Consultants

Pontiac, Michigan, United States, 48341

Principal Investigator: Fahd Al-Saghir, MD



Mayo Clinic

Rochester, Minnesota, United States, 55905

Principal Investigator: Vicente Torres, MD



Clinical Research Consultants, LLC

Kansas City, Missouri, United States, 64111

Principal Investigator: Ahmed Awad, MD


Washington University in St. Louis

Saint Louis, Missouri, United States, 63110

Principal Investigator: George Jarad, MD


New York

Nephrology Associates, P.C.

Flushing, New York, United States, 11355

Principal Investigator: Bruce Spinowitz, MD


North Carolina

Mountain Kidney & Hypertension Associates

Asheville, North Carolina, United States, 28801

Principal Investigator: Joseph Aiello, MD


Metrolina Nephrology Associates

Charlotte, North Carolina, United States, 28204

Principal Investigator: Peale Chuang, MD



University of Cincinnati College of Medicine

Cincinnati, Ohio, United States, 45267

Principal Investigator: Kotagal Kant, MD


Cleveland Clinic

Cleveland, Ohio, United States, 44195

Principal Investigator: Richard Fatica, MD


Remington-Davis Clinical Research

Columbus, Ohio, United States, 43215

Principal Investigator: Kevin Schroeder, MD



Northeast Clinical Research Center

Bethlehem, Pennsylvania, United States, 18017

Principal Investigator: Nelson Kopyt, MD


University of Pennsylvania

Philadelphia, Pennsylvania, United States, 19014

Principal Investigator: Simin Goral, MD


Children’s Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Principal Investigator: Kevin Meyers, MD


South Carolina

Columbia Nephrology Associates, PA

Columbia, South Carolina, United States, 29203

Principal Investigator: Asha Bailey, MD



Nephrology Associates, P.C.

Nashville, Tennessee, United States, 37205

Principal Investigator: Douglas Linfert, MD



Research Management, Inc.

Austin, Texas, United States, 78751

Principal Investigator: Judith Betts, MD


Research Management, Inc.

Austin, Texas, United States, 78758

Principal Investigator: Eileen Cook, MD


Renal Disease Research Institute

Dallas, Texas, United States, 75235

Principal Investigator: Ankit Mehta, MD


DaVita Med Center

Houston, Texas, United States, 77004

Principal Investigator: Stephen Fadem, MD


Clinical Advancement Center

San Antonio, Texas, United States, 78215

Principal Investigator: Pablo Pergola, MD



University of Vermont Medical Center

Burlington, Vermont, United States, 05401

Principal Investigator: Richard Solomon, MD



University of Virginia

Charlottesville, Virginia, United States, 22908

Principal Investigator: Sana Khan, MD



Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Principal Investigator: Ashraf El-Meanawy, MD


Australia: New South Wales, Queensland, South Australia, Victoria and Western Australia

Belgium: Brussels and Leuven

Czechia: Brno, Prague and Praha

France: Brest and Grenoble

Germany: Erlangen, Essen, Hanover and München

Italy: Milan and Napoli

Spain: Barcelona and Madrid

United Kingdom: Cambridge and London